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890702C

Avanti

16:0 EPC (Cl Salt)

Avanti Research™ - A Croda Brand 890702C

Synonym(s):

1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

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About This Item

Empirical Formula (Hill Notation):
C42H85NO8PCl
CAS Number:
328250-18-6
Molecular Weight:
798.55
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 1 mL (890702C-10mg)
pkg of 1 × 4 mL (890702C-100mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 890702C

concentration

10 mg/mL (890702C-10mg)
25 mg/mL (890702C-100mg)

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)OCC.[Cl-]

General description

16:0 EPC or 1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine is a P-O-ethyl derivative[1] and a saturated cationic lipid.[2]

Application

1,2-dipalmitoyl-sn-glycero-3-ethylphosphocholine (16:0 EPC (Cl Salt)):
  • has been used to design lipid nanoparticles of lower transition temperature, to enhance intracellular delivery mediated by shock waves[3]
  • is suitable for use as a cationic lipid to examine its miscibility and phase behavior with zwitterionic lipids[1]
  • may be used in liposome preparation[4]

Biochem/physiol Actions

Cationic lipids serve as a DNA and RNA transfecting agent. They behave as co-adjuvants for preparing vaccines and promote drug delivery. Ethyl phosphocholine (EPC) lipids resemble the cellular lipids, hence they are less toxic. They are also found to be metabolized by cells[1], as a result, they act as a potential non-viral transfection agent.[2]

Packaging

5 mL Clear Glass Sealed Ampule (890702C-100mg)
5 mL Clear Glass Sealed Ampule (890702C-10mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

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Eric A Smith et al.
Biophysical chemistry, 196, 86-91 (2014-12-03)
To examine the phase behavior of mixtures of zwitterionic and cationic lipids we used three derivatives of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). All three lipids are uniquely capable of spontaneously forming the interdigitated gel phase (LβI) under typical hydration conditions. The P-O-ethyl derivative
Costanza Montis et al.
Soft matter, 10(24), 4287-4297 (2014-05-03)
Ethylphosphocholine lipids are highly biocompatible cationic amphiphiles that can be used for the formulation of liposomal DNA vectors, with negligible toxic effects on cells and organisms. Here we report the characterization of EDPPC (1,2-dipalmitoyl-sn-glycero-O-ethyl-3-phosphocholine chloride) liposomes, containing two different zwitterionic
Eric A Smith et al.
Biophysical chemistry, 190-191, 1-7 (2014-04-22)
The effects of adding cis- and trans-unsaturated lipid to a fully interdigitated membrane were examined using differential scanning calorimetry (DSC) and X-ray diffraction. A monofluorinated analog of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) was used as the interdigitated lipid. The single fluorine atom on
Chu Wang et al.
Langmuir : the ACS journal of surfaces and colloids, 36(6), 1615-1622 (2020-01-23)
Body fluids flow all over the body and affect the biological processes at biointerfaces. To simulate such a case, sum frequency generation (SFG) vibrational spectroscopy and a self-designed microfluidic chip were combined together to investigate the interaction between a pH-responsive
Jing Zhang et al.
ACS applied materials & interfaces, 11(11), 10481-10491 (2019-02-23)
Cellular membranes are, in general, impermeable to macromolecules (herein referred to as macrodrugs, e.g., recombinant protein, expression plasmids, or mRNA), which is a major barrier for clinical translation of macrodrug-based therapies. Encapsulation of macromolecules in lipid nanoparticles (LNPs) can protect
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