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870608H

Avanti

4-HNE-dimethylacetal

Avanti Research™ - A Croda Brand 870608H, hexane solution

Synonym(s):

(E)-4R-hydroxynonenal-dimethylacetal (Each vial contains 6.8mg which yields ~5.2mg 4-HNE after deprotection)

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About This Item

Empirical Formula (Hill Notation):
C11H22O3
CAS Number:
119009-01-7
Molecular Weight:
202.29
UNSPSC Code:
12352211
NACRES:
NA.25

form

hexane solution

packaging

pkg of 1 × 1 mL (870608H-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 870608H

concentration

6.8 mg/mL (870608H-5mg)

lipid type

phosphoglycerides
bioactive lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCC[C@@H](O)/C=C/C(OC)OC

General description

4-Hydroxynonenal (4-HNE or HNE) is an α,β-unsaturated hydroxyalkenal which is produced by lipid peroxidation in cells. 4-HNE has been hypothesized by several researchers to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.
The dimethylacetal derivative is a more stable form of 4-HNE which is good for long term storage of the compound during use. It can be easily converted to 4-HNE in the presence of acid.

Packaging

2 mL Amber Glass Sealed Ampule (870608H-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3

target_organs

Central nervous system, Nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

-14.8 °F - closed cup

flash_point_c

-26.0 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

N4148

S-Nitrosoglutathione

Glutathione Assay Kit sufficient for 700 assays

Sigma-Aldrich

CS0260

Glutathione Assay Kit

On the role of 4-hydroxynonenal in health and disease
Csala M, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1852(5), 826-838 (2015)
Kamelija Zarkovic
Molecular aspects of medicine, 24(4-5), 293-303 (2003-08-02)
The development of oxidative stress, in which production of highly reactive oxygen species (ROS) overwhelms antioxidant defenses, is a feature of many neurological diseases: ischemic, inflammatory, metabolic and degenerative. Oxidative stress is increasingly implicated in a number of neurodegenerative disorders
N Zarković et al.
Life sciences, 65(18-19), 1901-1904 (1999-11-27)
Immunohistochemical analysis of the distribution of the lipid peroxidation product 4-hydroxynonenal (HNE) in the brain of baboons exposed to experimental hemorrhagic traumatic shock or sepsis showed that systemic oxidative stress and the thereby generated HNE affect the blood:brain barrier and
Yogesh C Awasthi et al.
Free radical biology & medicine, 37(5), 607-619 (2004-08-04)
4-Hydroxynonenal (HNE), one of the major end products of lipid peroxidation, has been shown to be involved in signal transduction and available evidence suggests that it can affect cell cycle events in a concentration-dependent manner. Glutathione S-transferases (GSTs) can modulate
Neven Zarkovic
Molecular aspects of medicine, 24(4-5), 281-291 (2003-08-02)
The review is focused on the currently major aspect of 4-hydroxynonenal (HNE) research--studies that combine biological activities of the aldehyde together with the methods of its identification in cells and tissues. Because there were some excellent reviews on HNE published
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