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840045P

Avanti

Brain PI(4)P

Avanti Research™ - A Croda Brand 840045P, powder

Synonym(s):

L-α-phosphatidylinositol-4-phosphate (Brain, Porcine) (ammonium Salt)

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About This Item

CAS Number:
475995-51-8
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (840045P-1mg)
pkg of 1 × 10 mg (840045P-10mg)
pkg of 1 × 25 mg (840045P-25mg)
pkg of 1 × 5 mg (840045P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 840045P

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP(O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)([O-])=O)[C@@H](O)[C@H]1O)([O-])=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]

InChI

1S/C47H84O16P2.2H3N/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(49)61-39(37-59-40(48)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2)38-60-65(57,58)63-47-44(52)42(50)46(43(51)45(47)53)62-64(54,55)56;;/h11,13,17,19,22,24,28,30,39,42-47,50-53H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3,(H,57,58)(H2,54,55,56);2*1H3/b13-11-,19-17-,24-22-,30-28-;;/t39-,42+,43?,44?,45?,46?,47-;;/m1../s1

InChI key

HJHASIMOAXACIC-CVKYTLMISA-N

General description

Phosphatidylinositol 4-phosphate (PI4P) acts as a precursor of phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2]. It is found in the membranes of Golgi apparatus.

Packaging

5 mL Clear Glass Sealed Ampule (840045P-10mg)
5 mL Clear Glass Sealed Ampule (840045P-1mg)
5 mL Clear Glass Sealed Ampule (840045P-25mg)
5 mL Clear Glass Sealed Ampule (840045P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Description
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Storage Class

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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PI4P and PI (4, 5) P2 are essential but independent lipid determinants of membrane identity
Hammond GRV, et al.
Science, 337(6095), 727-730 (2012)
Dieter R Klopfenstein et al.
Molecular biology of the cell, 15(8), 3729-3739 (2004-05-25)
UNC-104 (KIF1A) is a kinesin motor that transports synaptic vesicles from the neuronal cell body to the terminal. Previous in vitro studies have shown that a Dictyostelium relative of UNC-104 transports liposomes containing acidic phospholipids, but whether this interaction is
Jitendra Kumar et al.
PLoS genetics, 6(11), e1001200-e1001200 (2010-11-17)
UNC-104/KIF1A is a Kinesin-3 motor that transports synaptic vesicles from the cell body towards the synapse by binding to PI(4,5)P(2) through its PH domain. The fate of the motor upon reaching the synapse is not known. We found that wild-type
Ricarda A Busse et al.
Autophagy, 9(5), 770-777 (2013-03-01)
We characterized phosphoinositide binding of the S. cerevisiae PROPPIN Hsv2 qualitatively with density flotation assays and quantitatively through isothermal titration calorimetry (ITC) measurements using liposomes. We discuss the design of these experiments and show with liposome flotation assays that Hsv2
Dieter R Klopfenstein et al.
Cell, 109(3), 347-358 (2002-05-23)
Unc104 (KIF1A) kinesin transports membrane vesicles along microtubules in lower and higher eukaryotes. Using an in vitro motility assay, we show that Unc104 uses a lipid binding pleckstrin homology (PH) domain to dock onto membrane cargo. Through its PH domain
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