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W518107

Sigma-Aldrich

Sucrose acetate isobutyrate

Synonym(s):

SAIB

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About This Item

Empirical Formula (Hill Notation):
C40H62O19
Molecular Weight:
846.91
MDL number:
MFCD00041859
UNSPSC Code:
12164502
PubChem Substance ID:
24902076
NACRES:
NA.21

biological source

synthetic

Quality Level

400

grade

Kosher

bp

288 °C

density

1.146 g/mL at 25 °C

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

odorless

SMILES string

CC(C)C(=O)OC[C@]1(O[C@H](COC(C)=O)[C@@H](OC(=O)C(C)C)[C@@H]1OC(=O)C(C)C)O[C@H]2O[C@H](COC(C)=O)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@H]2OC(=O)C(C)C

InChI

1S/C40H62O19/c1-18(2)33(43)51-17-40(32(57-38(48)23(11)12)29(54-35(45)20(5)6)27(58-40)16-50-25(14)42)59-39-31(56-37(47)22(9)10)30(55-36(46)21(7)8)28(53-34(44)19(3)4)26(52-39)15-49-24(13)41/h18-23,26-32,39H,15-17H2,1-14H3/t26-,27-,28-,29-,30+,31-,32+,39-,40+/m1/s1

InChI key

ZNEBZIJCDDCNRC-SWTLDUCYSA-N

Application


  • An ultrasound-triggered injectable sodium alginate scaffold loaded with electrospun microspheres for on-demand drug delivery to accelerate bone defect regeneration.: This study highlights the use of Sucrose Acetate Isobutyrate (SAIB) in developing advanced drug delivery systems. SAIB is utilized to enhance the stability and controlled release properties of drug-loaded microspheres integrated into sodium alginate scaffolds, offering precise therapeutic management in bone regeneration applications (Yi Y et al., 2024).

  • Sustained Release of Dexamethasone from 3D-Printed Scaffolds Modulates Macrophage Activation and Enhances Osteogenic Differentiation.: Incorporating SAIB into 3D-printed scaffolds has shown to effectively control the release rates of dexamethasone, a therapeutic agent, facilitating improved osteogenic differentiation and reduced inflammatory responses, crucial for bone healing and regeneration (Majrashi M et al., 2023).

  • Application of Sucrose Acetate Isobutyrate in Development of Co-Amorphous Formulations of Tacrolimus for Bioavailability Enhancement.: Research demonstrates how SAIB can be used to develop co-amorphous drug formulations, specifically for tacrolimus, to enhance its bioavailability. This approach addresses significant challenges in drug solubility and stability, marking a significant advance in the formulation of poorly water-soluble drugs (Mohamed EM et al., 2023).

Disclaimer

For R&D or non-EU Food use. Not for retail sale.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Certificates of Analysis (COA)

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Rasmus I Jølck et al.
Advanced healthcare materials, 3(10), 1680-1687 (2014-04-16)
External beam radiation therapy relies on the ability to deliver high radiation doses to tumor cells with minimal exposure to surrounding healthy tissue. Advanced irradiation techniques, including image-guided radiation therapy (IGRT), rely on the ability to locate tumors to optimize
Jianbo Guo et al.
AAPS PharmSciTech, 16(4), 973-985 (2015-01-23)
Our previous studies revealed that the PLGA-based particulate systems loaded with cucurbitacin showed limited anti-melanoma efficiency in xenograft animal models after intratumoral injection, which was due to the undesirable initial burst release and the leakage of the particulate carriers from

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