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W291706

Sigma-Aldrich

Polysorbate 80

FG

Synonym(s):

TWEEN® 80, POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80

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About This Item

CAS Number:
9005-65-6
FEMA Number:
2917
MDL number:
MFCD00082107
UNSPSC Code:
12164502
E Number:
E 433
NACRES:
NA.21

biological source

palm oil
synthetic

Quality Level

400

grade

FG
Halal
Kosher

reg. compliance

EU Regulation 1333/2008 & 178/2002
FDA 21 CFR 172.515
FDA 21 CFR 172.836
FDA 21 CFR 172.838
FDA 21 CFR 172.840
FDA 21 CFR 172.842

vapor pressure

<1 mmHg ( 20 °C)

refractive index

n20/D 1.472 (lit.)

density

1.064 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

corn

organoleptic

alcohol

SMILES string

CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

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General description

Polysorbate 80 (TWEEN® 80) is a polyethylene sorbitol ester.

Application

Polysorbate 80 (TWEEN® 80), a hydrophilic non-ionic surfactant, is widely employed as a surfactant and solubilizing agent in food and cosmetic industries.

Legal Information

TWEEN is a registered trademark of Croda International PLC

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Storage Class

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flash_point_f

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flash_point_c

Not applicable

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hongjian Zhang et al.
Archives of pharmacal research, 26(9), 768-772 (2003-10-17)
Tween 80 (Polysorbate 80) is a hydrophilic nonionic surfactant commonly used as an ingredient in dosing vehicles for pre-clinical in vivo studies (e.g., pharmacokinetic studies, etc.). Tween 80 increased apical to basolateral permeability of digoxin in Caco-2 cells suggesting that
Stability characterization of a polysorbate 80-dimethyl trisulfide formulation, a cyanide antidote candidate.
Bartling CM, et al.
Drugs in R&D, 16(1), 109-127 (2016)
Use of Polysorbate 80 (Tween 80) as a phase-transfer catalyst.
Thoman CJ, et al.
The Journal of Organic Chemistry, 54(18), 4476-4478 (1989)
Tatiana Beldarrain-Iznaga et al.
Food research international (Ottawa, Ont.), 141, 110136-110136 (2021-03-02)
To provide their health effect, probiotics need to maintain their viability, adhere to the intestinal epithelium, and colonize it without losing their probiotic properties. In the present study, Lactobacillus casei was encapsulated in a double emulsion and then coated with
Asher Preska Steinberg et al.
Biomacromolecules, 20(7), 2675-2683 (2019-06-28)
Systems consisting of a polyelectrolyte solution in contact with a cross-linked polyelectrolyte network are ubiquitous (e.g., biofilms, drug-delivering hydrogels, and mammalian extracellular matrices), yet the underlying physics governing these interactions is not well understood. Here, we find that carboxymethyl cellulose

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