QBD10007

Biotin-dPEG^®₂₄-TFP ester

• Synonym(s): Polyethylene glycol
• Empirical Formula (Hill Notation): C₆₇H₁₁₇F₄N₃O₂₈S
• Molecular Weight: 1520.71
• UNSPSC Code: 12352108
• PubChem Substance ID: 329823871
• NACRES: NA.22

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reaction type: Biotinylations; reaction type: Biotinylations; reactivity: amine reactive; reagent type: cross-linking reagent
• polymer architecture: shape: linear; functionality: monofunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(CCCCC1SCC(N2)C1NC2=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(OC3=C(C(F)=CC(F)=C3F)F)=O
• InChI key: DZXHDWHQLGLRLF-UHFFFAOYSA-N

Description

Features and Benefits

The Biotin-dPEG^®₂₄-TFP ester has 2,3,5,6-tetrafluorophenyl (TFP) moiety which hydrolyze more slowly than NHS esters in aqueous media and are more reactive towards amines than NHS esters. The single molecular weight Biotin-dPEG^®₂₄-TFP ester has a long spacer of precise length (99.3 Å) between the biotin moiety and the labeled molecule. This dPEG spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable