We investigated the molecular mechanisms and the binding site location for the fluorophor crystal violet (CrV), a noncompetitive antagonist of the nicotinic acetylcholine receptor (AChR). To this end, radiolabeled competition binding, fluorescence spectroscopy, Schild-type analysis, patch-clamp recordings, and molecular dynamics
Plant physiology and biochemistry : PPB, 120, 194-201 (2017-10-22)
It is widely believed that pectin are responsible for the vast majority of cation binding positions in the root cell walls. To estimate the role of particular kinds of pectin, we studied the cell wall material isolated from the roots
International journal of peptide and protein research, 17(2), 170-180 (1981-02-01)
The interaction of the cholinergic fluorescent probes, 1-(5-dimethyl-aminoaphthalene-1-sulfonamido) ethane-2-trimethylammonium perchlorate, 1-(5-dimethylaminoaphthalene-1-sulfonamido) pentane-5-trimethylammonium tartarate and 1-(5-dimethylaminonaphthalene-1-sulfonamido) decane-10- trimethylammonium tartarate with horse serum cholinesterase has been examined by fluorescence and n.m.r. methods. Fluorescence titrations show binding of the decane derivative to two
Agonists of Torpedo nicotinic receptors: essential role of a positive charge.
A Y Jeng et al.
Annals of the New York Academy of Sciences, 358, 370-373 (1980-01-01)
Decades of research implicates perfectionism in depressive symptoms. Yet, inconsistent findings, underpowered studies, and the tendency for researchers to assume one direction of influence have clouded understanding of whether perfectionism is a vulnerability factor for depressive symptoms, a complication of
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