CPGG-502

Anionic PEGylated Liposomes

DOPC:Chol:DOPG:DOPE-PEG(2000) (60:30:5:5 molar ratio 10mM)

• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Quality Level: 100
• composition: Phosphate buffered saline
• concentration: 10 mM
• impurities: 30 mol % Cholesterol ; 5 mol % DOPE-PEG2000; 5 mol % DOPG; 60 mol % DOPC
• particle size: 100 nm
• pH: 7.4

Description

General description

Poly(ethylene glycol) (PEG) is commonly added to liposomes to improve stability, hydrophilicity and enhance circulation time. Anionic PEGylated liposomes protect liposomes from circulating proteins, improving their plasma clearance and enhancing their therapeutic effects. In addition, anionic liposomes demonstrate greater stability in solution, lead to lower aggregation when compared to neutral liposomes, and have increased endocytosis when compared with cationic and neutral liposomes.

Application

Drug delivery
Lipid-protein interactions

Storage and Stability

Liposomes should never be frozen. Liposomes should be stored in the dark at 4°C, except when brought to room temperature for brief periods prior to use.

Liposomes are made under sterile conditions. If you need to take multiple aliquots out of the vial, it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product. Liposomes should never be frozen. Ice crystals that form during freezing will rupture the lipid membrane of the liposomes and change the size of liposomes particles.

Legal Information

Cellsome is a trademark of Encapsula NanoSciences

Product of Encapsula Nanosciences

Disclaimer

For research use only

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable