The patch-clamp technique was used to examine the sensitivity of delayed rectifier K+ channels to changes in intracellular divalent cations (Mg2+ and Ca2+). During voltage-step and ramp depolarizations, a delayed rectifier K+ current (IK(dr)) was identified in renal, pulmonary, coronary
British journal of pharmacology, 177(3), 614-622 (2018-12-28)
Th9 cells represent a recently defined subset of CD4+ T-helper cells, characterized by a high production of IL-9. They are found at increased frequency in lesions of atopic dermatitis, where IL-9 is also elevated. As histamine is up-regulated in lesions
American journal of respiratory cell and molecular biology, 18(5), 721-730 (1998-06-06)
High levels of histamine can be found in the airways of asthma patients. This study describes the effects of histamine on anti-CD3-induced production of IL-4, IL-5, and IFN-gamma by T cell clones from subjects with allergic asthma and healthy subjects.
The Journal of pharmacology and experimental therapeutics, 271(2), 1016-1026 (1994-11-01)
The receptors involved in the neural and non-neural effects of histamine on the canine proximal colon in vitro were defined functionally by using selective agonists and antagonists. Two preparations, a ganglionated mucosa and an aganglionated epithelium, were set up in
British journal of pharmacology, 177(3), 600-613 (2019-07-23)
Human monocyte-derived M1 macrophages develop in relation to growth factors, bacterial products, and cytokines in a local micro-environment. M1 macrophages produce pro-inflammatory mediators, in particular, oncostatin M (OSM), which is secreted from the cells in response to the active complement
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