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936391

Sigma-Aldrich

Fmoc-Gly-Gly-OH

≥95%

Synonym(s):

Fmoc-Gly-Gly-OH, 2-[2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)acetamido]acetic acid, N-9-Fluorenylmethoxycarbonylglycylglycine, N-Fluorenylmethoxycarbonylglycylglycine, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine (ACI), Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl- (9CI, ACI), Glycine, N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl]- (ZCI)

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About This Item

Empirical Formula (Hill Notation):
C19H18N2O5
CAS Number:
35665-38-4
Molecular Weight:
354.36
MDL number:
MFCD00190880
UNSPSC Code:
12352106
NACRES:
NA.22

Quality Level

100

assay

≥95%

form

powder or crystals

color

white to off-white

storage temp.

2-8°C

SMILES string

O=C(OCC1C=2C=CC=CC2C=3C=CC=CC31)NCC(=O)NCC(=O)O

InChI

1S/C19H18N2O5/c22-17(20-10-18(23)24)9-21-19(25)26-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,20,22)(H,21,25)(H,23,24)

Application

Fmoc-Gly-Gly-OH is a lysosomally cleavable linker used in construction of antibody-drug conjugates (ADC & Bioconjugation).

Other Notes

Chemical Biology Tools

http://pubs.rsc.org/en/Content/ArticleLanding/2011/MB/C0MB00074D#!divAbstract

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Alain Beck et al.
Nature reviews. Drug discovery, 16(5), 315-337 (2017-03-18)
Antibody-drug conjugates (ADCs) are one of the fastest growing classes of oncology therapeutics. After half a century of research, the approvals of brentuximab vedotin (in 2011) and trastuzumab emtansine (in 2013) have paved the way for ongoing clinical trials that

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