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918946

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)

PEG average Mn 5000, PDLLA average Mn 20000

Synonym(s):

Biodegradable, Block copolymer, Drug delivery, PEG-PLA, PLLA, mPEG-PLA, mPEG-PLLA

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About This Item

Linear Formula:
HO[CH(CH3)COO]m[CH2CH2O]nCH3
UNSPSC Code:
12352106
NACRES:
NA.23

form

powder or chunks

Quality Level

100

mol wt

PDLA average Mn 20,000 (by NMR)
PDLLA average Mn 20000
PEG average Mn 5,000 (by NMR)
PEG average Mn 5000

color

white to beige

storage temp.

2-8°C

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Application

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide) is an amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLA block.These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics).

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

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Ren Zhong Xiao et al.
International journal of nanomedicine, 5, 1057-1065 (2010-12-21)
Due to their small particle size and large and modifiable surface, nanoparticles have unique advantages compared with other drug carriers. As a research focus in recent years, polyethylene glycol-polylactic acid (PEG-PLA) block copolymer and its end-group derivative nanoparticles can enhance
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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