910813

mPEG₂₄-NHS

• Synonym(s): Methoxypolyethylene glycol acetic acid N-succinimidyl ester, mPEG NHS
• Empirical Formula (Hill Notation): C₅₆H₁₀₇NO₂₉
• CAS Number: 174569-25-6
• Molecular Weight: 1258.44
• MDL number: MFCD28385538
• UNSPSC Code: 43211915
• NACRES: NA.23

Properties

• assay: 95% (HPLC)
• form: solid
• mol wt: average M_n 1,250 (by NMR)
• reaction suitability: reagent type: chemical modification reagent; reactivity: amine reactive
• color: white to off-white
• Ω-end: NHS ester
• α-end: methoxy
• polymer architecture: shape: linear; functionality: monofunctional
• storage temp.: −20°C
• SMILES string: N1(C(=O)CCC1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
• InChI: 1S/C56H107NO29/c1-61-6-7-63-10-11-65-14-15-67-18-19-69-22-23-71-26-27-73-30-31-75-34-35-77-38-39-79-42-43-81-46-47-83-50-51-85-53-52-84-49-48-82-45-44-80-41-40-78-37-36-76-33-32-74-29-28-72-25-24-70-21-20-68-17-16-66-13-12-64-9-8-62-5-4-56(60)86-57-54(58)

Description

Application

Polyethylene glycols (PEGs) are FDA approved hydrophilic polymers. They are non-toxic, non-immunogenic and non-antigenic, and are widely used in a variety of biomedical applications such as bioconjugation, drug delivery, surface functionalization, and tissue engineering. PEG-NHS is an amine reactive PEG that can react to amino groups of lysine(s) on proteins or other biologics; reaction occurs at room temperature in <1hr at pH 7-8. Stable linker between PEG and NHS ester.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: >230.0 °F
• flash_point_c: > 110 °C