910015

17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid

≥95%

• Synonym(s): Azido-PEG₅-CH₂CO₂H, Azido-PEG₅-acid, N₃-PEG₅-CH₂COOH
• Empirical Formula (Hill Notation): C₁₂H₂₃N₃O₇
• CAS Number: 217180-81-9
• Molecular Weight: 321.33
• MDL number: MFCD31561141
• UNSPSC Code: 12352106

Properties

• assay: ≥95%
• form: (Liquid or Semi-solid or Paste or Solid)
• reaction suitability: reaction type: click chemistry; reagent type: cross-linking reagent
• functional group: azide; carboxylic acid
• storage temp.: 2-8°C
• SMILES string: OC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O

Description

Application

This heterobifunctional, PEGylated crosslinker 17-Azido-3,6,9,12,15-pentaoxaheptadecanoic acid features a carboxyl group at one end and azide at the other. The hydrophillic PEG linker facilitates solubility in biological applications. This azido-PEG₅-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable