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908533

Sigma-Aldrich

Poly(D,L-lactide-b-glycolide) lactide:glycolide 50:50

diamine, viscosity 0.035 dL/g 

Synonym(s):

Amino-functionalized PLGA, NH2-PLGA-NH2, PLGA diamine

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About This Item

Linear Formula:
C6H11N4O3(C2H2O2)y-1(C3H4O2)xC4H4O4(C3H4O2)x(C2H2O2)y-1C6H11N4O3
UNSPSC Code:
12162002
NACRES:
NA.23

form

powder or chunks

feed ratio

lactide:glycolide 50:50

color

white to tan

viscosity

0.035 dL/g

storage temp.

−20°C

Application

Biocompatible and biodegradable polymer can be used in the formation of nanoparticles for drug delivery. The amine functional groups on both chain ends enable rapid and facile surface functionalization, allowing for this material to be used in applications such as targeted drug delivery.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact
R Gref et al.
Science (New York, N.Y.), 263(5153), 1600-1603 (1994-03-18)
Injectable nanoparticulate carriers have important potential applications such as site-specific drug delivery or medical imaging. Conventional carriers, however, cannot generally be used because they are eliminated by the reticulo-endothelial system within seconds or minutes after intravenous injection. To address these

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