742600
Difluoromethyl phenyl sulfone
≥97%
Synonym(s):
PhSO2CF2H, [(Difluoromethyl)sulfonyl]benzene
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1 G
$84.80
10 G
$493.00
About This Item
Empirical Formula (Hill Notation):
C7H6F2O2S
CAS Number:
Molecular Weight:
192.18
Beilstein/REAXYS Number:
2259218
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
assay
≥97%
form
solid
functional group
fluoro
sulfone
SMILES string
FC(F)S(=O)(=O)c1ccccc1
InChI
1S/C7H6F2O2S/c8-7(9)12(10,11)6-4-2-1-3-5-6/h1-5,7H
InChI key
LRHDNAVPELLXDL-UHFFFAOYSA-N
Application
Reagent Used for
Reagent used in Preparation of
- Reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes[1]
- Fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors[2]
- Difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation[3]
Reagent used in Preparation of
- α-difluoromethyl amines via stereoselective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines[4]
- Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes[5]
- β-difluoromethylated and β-difluoromethylenated alcohols and amines by regioselective nucleophilic difluoromethylation of 1,2-cyclic sulfates and sulfamidates[6]
- Difluoroalkenes from alkyl halides via nucleophilic substitution-elimination[7]
- Difluoromethyl alcohol derivatives from enolizable and non-enolizable carbonyl compounds using nucleophilic phenylsulfonyldifluoromethylation-reductive desulfonylation strategy[8]
- Fluoromethylated vicinal ethylenediamines via fluoromethylation of chiral α-aminobutanesulfinimines with (phenylsulfonyl)fluoromethanes followed by reductive desulfonylation and alcoholysis[9]
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
264.0 °F
flash_point_c
128.9 °C
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Facile synthesis of chiral alpha-difluoromethyl amines from N-(tert-butylsulfinyl)aldimines.
Ya Li et al.
Angewandte Chemie (International ed. in English), 44(36), 5882-5886 (2005-09-09)
G K Surya Prakash et al.
Organic letters, 6(23), 4315-4317 (2004-11-05)
A facile and efficient nucleophilic difluoromethylation of primary alkyl halides has been disclosed through a novel nucleophilic substitution-reductive desulfonylation strategy, using difluoromethyl phenyl sulfone as a difluoromethyl anion ("CF(2)H(-)") equivalent.
Convenient synthesis of difluoromethyl alcohols from both enolizable and non-enolizable carbonyl compounds with difluoromethyl phenyl sulfone
Prakash, G. K. S.; et al.
European Journal of Organic Chemistry, 11, 2218-2223 (2005)
Difluoromethyl phenyl sulfone as a selective difluoromethylene dianion equivalent: one-pot stereoselective synthesis of anti-2,2-difluoropropane-1,3-diols.
G K Surya Prakash et al.
Angewandte Chemie (International ed. in English), 42(42), 5216-5219 (2003-11-06)
A remarkably efficient fluoroalkylation of cyclic sulfates and sulfamidates with PhSO2CF2H: facile entry into beta-difluoromethylated or beta-difluoromethylenated alcohols and amines.
Chuanfa Ni et al.
Angewandte Chemie (International ed. in English), 46(5), 786-789 (2006-12-14)
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