687901

4-(Trifluoromethoxy)phenylmagnesium bromide solution

0.5 M in THF

• Empirical Formula (Hill Notation): C₇H₄BrF₃MgO
• Molecular Weight: 265.31
• MDL number: MFCD09842767
• UNSPSC Code: 12352103
• PubChem Substance ID: 329760826
• NACRES: NA.22

Properties

• form: liquid
• reaction suitability: reaction type: Grignard Reaction
• concentration: 0.5 M in THF
• density: 0.975 g/mL at 25 °C
• SMILES string: FC(F)(F)Oc1ccc([Mg]Br)cc1
• InChI: 1S/C7H4F3O.BrH.Mg/c8-7(9,10)11-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1
• InChI key: UFMHNMPAQCQXMW-UHFFFAOYSA-M

Description

Application

Reactant for:

• Preparation of chromanol derivatives as novel class of CETP inhibitors for treatment of cardiovascular disease
• Pd-catalyzed cross coupling
• Preparation of indazole-pyridine derivatives as protein kinase B/Akt inhibitors with reduced hypotension, via Stille coupling, Mitsunobu reaction and copper-catalyzed aziridine ring-opening reaction

Safety Information

• pictograms: GHS02,GHS08,GHS05,GHS07
• signalword: Danger
• hcodes: H225,H302,H314,H335,H336,H351
• pcodes: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• target_organs: Respiratory system
• supp_hazards: EUH014,EUH019
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: -22.0 - -4.0 °F - closed cup
• flash_point_c: -30 - -20 °C - closed cup