679585

4-Methoxybenzyl-2,2,2-trichloroacetimidate

• Synonym(s): p-Methoxybenzyl trichloroacetimidate
• Empirical Formula (Hill Notation): C₁₀H₁₀Cl₃NO₂
• CAS Number: 89238-99-3
• Molecular Weight: 282.55
• MDL number: MFCD00134547
• UNSPSC Code: 12352101
• PubChem Substance ID: 24885502
• NACRES: NA.22

Properties

• impurities: Major impurity is Trichloroacetamide by GCMS.
• refractive index: n20/D 1.5488
• bp: 135-137 °C/0.7 mmHg
• density: 1.361 g/mL at 25 °C
• storage temp.: 2-8°C
• SMILES string: COc1ccc(COC(=N)C(Cl)(Cl)Cl)cc1
• InChI: 1S/C10H10Cl3NO2/c1-15-8-4-2-7(3-5-8)6-16-9(14)10(11,12)13/h2-5,14H,6H2,1H3
• InChI key: TYHGKLBJBHACOI-UHFFFAOYSA-N

Description

Application

4-Methoxybenzyl-2,2,2-trichloroacetimidate can be used as a reagent for the protection of alcohols as the p-methoxybenzyl ether. 1^o, 2^o, and 3^o alcohols can be easily protected using this reagent with equal efficiency in the presence of a variety of different protective groups. This reagent is commonly used under acidic conditions therefore it offers an alternative method to the Williamson ether synthesis, which is typically used basic conditions to protect base-sensitive alcohols.

Safety Information

• pictograms: GHS07,GHS09
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319,H335,H411
• pcodes: P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: >230.0 °F
• flash_point_c: > 110 °C