564990

N,N-Diethyl-1,1,2,3,3,3-hexafluoropropylamine

• Synonym(s): Ishikawa’s Reagent
• Linear Formula: CF₃CHFCF₂N(C₂H₅)₂
• CAS Number: 309-88-6
• Molecular Weight: 223.16
• MDL number: MFCD00054683
• UNSPSC Code: 12352101
• PubChem Substance ID: 24880211
• NACRES: NA.22

Properties

• Quality Level: 100
• refractive index: n20/D 1.3460 (lit.)
• bp: 56-57 °C (lit.)
• density: 1.230 g/mL at 25 °C (lit.)
• SMILES string: CCN(CC)C(F)(F)C(F)C(F)(F)F
• InChI: 1S/C7H11F6N/c1-3-14(4-2)7(12,13)5(8)6(9,10)11/h5H,3-4H2,1-2H3
• Inchi Key: BNTFCVMJHBNJAR-UHFFFAOYSA-N

Description

General description

GC analysis includes Et₂NCF=CFCF₃ (two isomers), both of which are active fluorinating agents.

Application

Reactant for:

• Friedel-Crafts type arylation of hydrofluorocarbons
• Microbial hydroxylation of antibiotics
• Electrochemical fluorination of trialkylamines and tetraalkylammonium salts
• Fluorination of pyrethroides

Reactant for synthesis of:

• γ-Hydroxy-α-fluoro-α-trifluoromethylcarboxamide
• Florfenicol and thiamphenicol

Demonstrates utility in fluorination.

Displays the ability to insert a fluoro(trifluoromethyl) methylene moiety in unsaturated alcohols.

Safety Information

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H226,H314
• pcodes: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Flam. Liq. 3 - Skin Corr. 1B
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 104.0 °F - closed cup
• flash_point_c: 40 °C - closed cup
• ppe: Faceshields, Gloves, Goggles