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540323

Sigma-Aldrich

1,1,1-Trifluoro-2-propanol

97%

Synonym(s):

1,1,1-Trifluoroisopropanol, 1,1,1-Trifluoropropane-2-ol, 1-(Trifluoromethyl)ethanol, 1-Methyl-2,2,2-trifluoroethanol

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25 G
$234.00

$234.00

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25 G
$234.00

About This Item

Linear Formula:
CF3CH(OH)CH3
CAS Number:
374-01-6
Molecular Weight:
114.07
EC Number:
206-773-2
MDL number:
MFCD00014403
UNSPSC Code:
12352100
PubChem Substance ID:
24878458
NACRES:
NA.22
assay:
97%

$234.00

In StockDetails

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Quality Level

100

assay

97%

refractive index

n20/D 1.316 (lit.)

bp

81-82 °C (lit.)

density

1.259 g/mL at 25 °C (lit.)

functional group

fluoro
hydroxyl

SMILES string

CC(O)C(F)(F)F

InChI

1S/C3H5F3O/c1-2(7)3(4,5)6/h2,7H,1H3

InChI key

GILIYJDBJZWGBG-UHFFFAOYSA-N

General description

1,1,1-Trifluoro-2-propanol, a fluoroalcohol, is an organic solvent.[1] Vibrational spectral analysis of OH and OD groups of 1,1,1-trifluoro-2-propanol and its deuterated derivatives has been conducted.[2]

Application

1,1,1-Trifluoro-2-propanol may be used in the synthesis of 1,1,1-trifluoropropan-2-yl 2-(4-hydroxy-3-methoxyphenyl)acetate and 1,1,1-trifluoropropan-2-yl 2-(3-ethoxy-4-hydroxyphenyl)acetate.[3]

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

64.9 °F - closed cup

flash_point_c

18.3 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW6969
MKCV5936
MKCS9899
MKCQ9736
MKCP8966

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Synthetic mammalian prions.
Legname G, et al.
Science, 305, 673-676 (2004)
Fluoroalcohols-XXI. Infrared, matrix infrared and Raman spectra of 1, 1, 1-trifluoro-2-propanol and its three deuterated analogues.
Murto J, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 31(4), 479-493 (1975)
Heng Zhang et al.
PloS one, 9(5), e96518-e96518 (2014-05-07)
Soft drugs are molecules that are purposefully designed to be rapidly metabolized (metabolically labile). In anesthesia, the soft drug is useful because it enables precise titration to effect and rapid recovery, which might allow swift and clear-headed recovery of consciousness

Questions

  1. Is there a method to determine the assay value? If so, what is it? or at least the solvent that is used.

    1 answer

    1. This product has a Quality Level 100. Methods of preparation are considered proprietary for products with Quality Level 100. However, the following publications may be helpful:

      https://pubchem.ncbi.nlm.nih.gov/compound/9774
      https://www.benchchem.com/product/b1588066
      https://patents.google.com/patent/EP2511376B1/en

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