Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

532711

Sigma-Aldrich

2-Fluorobenzenesulfonyl chloride

2-Fluorobenzenesulfonyl chloride

97%

Sign Into View Organizational & Contract Pricing

Select a Size

5 G
$57.76

$57.76

List Price$60.80
Web-Only Promotion

Available to ship onApril 22, 2025Details


Request a Bulk Order

Select a Size

Change View
5 G
$57.76

About This Item

Linear Formula:
FC6H4SO2Cl
CAS Number:
Molecular Weight:
194.61
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

$57.76

List Price$60.80
Web-Only Promotion

Available to ship onApril 22, 2025Details


Request a Bulk Order

Quality Level

assay

97%

refractive index

n20/D 1.537 (lit.)

bp

246-247 °C (lit.)

mp

27-30 °C (lit.)

density

1.47 g/mL at 25 °C (lit.)

functional group

fluoro

SMILES string

Fc1ccccc1S(Cl)(=O)=O

InChI

1S/C6H4ClFO2S/c7-11(9,10)6-4-2-1-3-5(6)8/h1-4H

InChI key

ZSZKAQCISWFDCQ-UHFFFAOYSA-N

General description

2-Fluorobenzenesulfonyl chloride, also known as o-fluorobenzenesulfonyl chloride, is a flurinated arylsulfonyl chloride. It can be prepared from o-benzenedisulfonyl fluoride. [1]

Application

2-Fluorobenzenesulfonyl chloride may be used in the preparation of the following furan derivatives:
  • 2-(2-fluorophenyl)benzofuran[2]
  • 2-butyl-5-(2-fluorophenyl)furan[3]
  • 2-(2-fluorophenyl)-3,6-dimethyl-4,5,6,7-tetrahydrobenzofuran[3]

It may also be used to prepare:
  • 2-fluorobenzenesulfonamide[4]
  • methyl 2-{[(2-fluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate[5]
  • potassium fluorobenzene-2-sulfonate[6]
  • 1-(2-bromobenzyl)-2-(2-fluorophenyl)pyrrole[7]

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Regiocontroled Palladium?Catalysed Direct Arylation at Carbon C2 of Benzofurans using Benzenesulfonyl Chlorides as the Coupling Partners.
Loukotova L, et al.
ChemCatChem, 6(5), 1303-1309 (2014)
Water-Soluble Phosphines. 6.1 Tailor-Made Syntheses of Chiral Secondary and Tertiary Phosphines with Sulfonated Aromatic Substituents: Structural and Quantum Chemical Studies.
Bitterer F, et al.
Inorganic Chemistry, 35(14), 4103-4113 (1996)
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
Sheppard GS, et al.
Journal of Medicinal Chemistry, 49(13), 3832-3849 (2006)
Benzenesulfonyl Chlorides: Alternative Coupling Partners for Regiocontrolled Palladium-Catalyzed Direct Desulfitative 5-Arylation of Furans.
Beladhria A, et al.
Synthesis, 46(18), 2515-2523 (2014)
Potassium fluoride catalyzed fluorodesulfonylations of aryl sulfonyl fluorides.
Van der Puy M.
The Journal of Organic Chemistry, 53(18), 4398-4401 (1988)

Questions

Reviews

Active Filters

    • Reviews 2
    • Votes 0
    5 out of 5 stars.

    Excellent sulfonyl chloride

    great high quality product and fast delivery - excellent communication about delivery times

    Helpful?

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service