452920

Trimethyl borate

≥98%

• Synonym(s): Boric acid trimethyl ester, Methyl borate
• Linear Formula: B(OCH₃)₃
• CAS Number: 121-43-7
• Molecular Weight: 103.91
• Beilstein/REAXYS Number: 1697939
• EC Number: 204-468-9
• MDL number: MFCD00008346
• UNSPSC Code: 12352103
• PubChem Substance ID: 24868738
• NACRES: NA.22

Properties

• vapor density: 3.59 (vs air)
• Quality Level: 200
• assay: ≥98%
• refractive index: n20/D 1.346 (lit.)
• bp: 68-69 °C (lit.)
• mp: −34 °C (lit.)
• density: 0.932 g/mL at 20 °C (lit.)
• SMILES string: COB(OC)OC
• InChI: 1S/C3H9BO3/c1-5-4(6-2)7-3/h1-3H3
• InChI key: WRECIMRULFAWHA-UHFFFAOYSA-N

Description

Application

Trimethyl borate reacts with a Grignard reagent or organolithium compounds to yield dimethyl boronates, which upon subsequent aqueous acid treatment afford corresponding boronic acids. The resultant boronic acids or esters are useful intermediates in various cross-coupling reactions such as Suzuki coupling and Chan-Lam coupling. It is also used in the preparation of sodium borohydride.

Legal Information

ASCENSUS product

Safety Information

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H319,H360FD,H370
• pcodes: P210 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B - STOT SE 1
• target_organs: Eyes
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 12.2 °F - (own results)
• flash_point_c: -11 °C - (own results)
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter