448427

(4R)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-oxide

98%

• Synonym(s): (2R,4R)-5,5-Dimethyl-2-hydroxy-4-phenyl-1,3,2-dioxaphosphorinan 2-oxide, (R)-(−)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinane 2-oxide
• Empirical Formula (Hill Notation): C₁₁H₁₅O₄P
• CAS Number: 98674-80-7
• Molecular Weight: 242.21
• Beilstein/REAXYS Number: 4294714
• MDL number: MFCD00044976
• UNSPSC Code: 12352005
• PubChem Substance ID: 24868406
• NACRES: NA.22

Properties

• assay: 98%
• optical activity: [α]20/D −62°, c = 0.5 in methanol
• impurities: <5% water
• mp: 224-227 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: CC1(C)COP(O)(=O)O[C@@H]1c2ccccc2
• InChI: 1S/C11H15O4P/c1-11(2)8-14-16(12,13)15-10(11)9-6-4-3-5-7-9/h3-7,10H,8H2,1-2H3,(H,12,13)/t10-/m1/s1
• InChI key: PSZSDCWNBXVDFG-SNVBAGLBSA-N

Description

Application

(4R)-2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-oxide can be used:

• As a reactant in the phosphoalkoxylation of aromatic enones.
• As a chiral resolving agent in the resolution of amino acids, amines, and amino alcohols.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves