399086

Triethyl 2-chloro-2-phosphonoacetate

97%

• Synonym(s): Chloro(diethoxyphosphinyl)acetic acid ethyl ester
• Linear Formula: (C₂H₅O)₂P(O)CH(Cl)CO₂C₂H₅
• CAS Number: 7071-12-7
• Molecular Weight: 258.64
• MDL number: MFCD00192516
• UNSPSC Code: 12352101
• PubChem Substance ID: 24864786
• NACRES: NA.22

Properties

• assay: 97%
• form: liquid
• reaction suitability: reaction type: C-C Bond Formation
• refractive index: n20/D 1.446 (lit.)
• bp: 93-95 °C/0.01 mmHg (lit.)
• density: 1.21 g/mL at 25 °C (lit.)
• SMILES string: CCOC(=O)C(Cl)P(=O)(OCC)OCC
• InChI: 1S/C8H16ClO5P/c1-4-12-8(10)7(9)15(11,13-5-2)14-6-3/h7H,4-6H2,1-3H3
• InChI key: PCDXCIMROXIFBI-UHFFFAOYSA-N

Description

Application

Reactant involved in:

• Synthesis of purine nucleoside derivatives containing a halogen atom
• Horner-Wadsworth-Emmons reactions
• Scale-up production of bacterial topoisomerase inhibitors
• Synthesis of galbonolide derivatives
• Stereoselective Horner reaction for preparation of vinylogous peptides

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 235.4 °F - closed cup
• flash_point_c: 113 °C - closed cup
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter