380253
Ethyl pipecolinate hydrochloride
97%
Synonym(s):
Ethyl 2-piperidinecarboxylate hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C8H15NO2 · HCl
CAS Number:
Molecular Weight:
193.67
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
assay
97%
mp
211-213 °C (lit.)
SMILES string
Cl[H].CCOC(=O)C1CCCCN1
InChI
1S/C8H15NO2.ClH/c1-2-11-8(10)7-5-3-4-6-9-7;/h7,9H,2-6H2,1H3;1H
InChI key
KGAWPIXNSIYQPC-UHFFFAOYSA-N
General description
Ethyl pipecolinate hydrochloride is a heterocyclic building block. It is reported to participate in the total synthesis of the (+)-epiquinamide, a quinolizidine alkaloid.
Application
Ethyl pipecolinate hydrochloride (Ethyl 2-piperidinecarboxylate hydrochloride) may be used in the preparation of:
- 1,4-diazabicyclo[4.4.0]decane
- small molecule inhibitors of Legionella MIP protein
- antiinflammatory and analgesic molecules
- anti-amnesic agents
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Syntheses of 1, 4-Diazabicyclo [4.4. 0] decanes, 1, 4-Diazabicyclo [4.3. 0] nonanes and 1, 8-Diazabicyclo [4.3. 0] nonanes.
Freed ME and Day AR.
J. Org. React., 25(12), 2108-2113 (1960)
G. A. Gevorgyan, et al.,
Khim.-Farm. Zh., 37, 152-154 (2003)
A concise synthesis of (?) and a total synthesis of (+)-epiquinamide.
Tong STA and Barker D.
Tetrahedron Letters, 47(29), 5017-5020 (2006)
S Zhao et al.
Bioorganic & medicinal chemistry, 7(8), 1637-1646 (1999-09-11)
Tacrine, one of the drugs available for Alzheimer's disease based on the cholinergic approach, suffers from considerable toxicity. Many analogues of tacrine have been prepared which retain the pharmacologically rich aminopyridine or aminoquinoline motifs. The current research was undertaken to
Christina Juli et al.
Journal of medicinal chemistry, 54(1), 277-283 (2010-12-15)
The macrophage infectivity potentiator (MIP) protein is a major virulence factor of Legionella pneumophila, the causative agent of Legionnaires' disease. MIP belongs to the FK506-binding proteins (FKBP) and is necessary for optimal intracellular survival and lung tissue dissemination of L.
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