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204072

Sigma-Aldrich

cis-Diammineplatinum(II) dichloride

Synonym(s):

cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin

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About This Item

Linear Formula:
Pt(NH3)2Cl2
CAS Number:
15663-27-1
Molecular Weight:
300.05
EC Number:
239-733-8
MDL number:
MFCD00011623
UNSPSC Code:
12352300

mp

270 °C (lit.)

SMILES string

N.N.Cl[Pt]Cl

InChI

1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

InChI key

LXZZYRPGZAFOLE-UHFFFAOYSA-L

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Application

Possesses antitumor activity.[1][2][3][4][5]

Biochem/physiol Actions

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

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Certificates of Analysis (COA)

Lot/Batch Number
02427AP
01215KW
09420MW
7115JS
14615TB

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V K Ghanta et al.
Cancer research, 40(7), 2372-2376 (1980-07-01)
MOPC 104E myeloma cells are brought under host regulation after treatment with cyclophosphamide, 1,3-bis(2-chloroethyl)-1-nitrosourea, or cis-dichlorodiammineplatinum(II). The first indication of this phenomenon is the plateau level of immunoglobulin M(lambda) [IgM(lambda)]. The myeloma recurs more frequently in animals with high plateau
Inhibition of the BamHI cleavage and unwinding of pBR322 deoxyribonucleic acid by the antitumor drug cis-dichlorodiammineplatinum(II).
H M Ushay et al.
Biochemistry, 20(13), 3744-3748 (1981-06-23)
Clinical and pharmacological studies with cis-diamminedichloroplatinum (II).
R C DeConti et al.
Cancer research, 33(6), 1310-1315 (1973-06-01)
R D Christen et al.
The Journal of clinical investigation, 92(1), 431-440 (1993-07-01)
We have previously shown that forskolin and 3-isobutyl-1-methylxanthine (IBMX) increased accumulation of cisplatin (DDP) in DDP-sensitive 2008 human ovarian carcinoma cells in proportion to their ability to increase cAMP. Since the major function of cAMP is to activate protein kinase
Platinum compounds: a new class of potent antitumour agents.
B Rosenberg et al.
Nature, 222(5191), 385-386 (1969-04-26)
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