193135

3,5-Bis(trifluoromethyl)aniline

97%

• Synonym(s): α,α,α,α′,α′,α′-Hexafluoro-3,5-xylidine, 5-Amino-α,α,α,α′,α′,α′-hexafluoro-m-xylene
• Linear Formula: (CF₃)₂C₆H₃NH₂
• CAS Number: 328-74-5
• Molecular Weight: 229.12
• Beilstein/REAXYS Number: 654318
• EC Number: 206-335-0
• MDL number: MFCD00000394
• UNSPSC Code: 12352100
• PubChem Substance ID: 24851584
• NACRES: NA.22

Properties

• assay: 97%
• form: liquid
• refractive index: n20/D 1.434 (lit.)
• bp: 85 °C/15 mmHg (lit.)
• density: 1.467 g/mL at 25 °C (lit.)
• SMILES string: Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
• InChI: 1S/C8H5F6N/c9-7(10,11)4-1-5(8(12,13)14)3-6(15)2-4/h1-3H,15H2
• InChI key: CDIDGWDGQGVCIB-UHFFFAOYSA-N

Description

Application

3,5-Bis(trifluoromethyl)aniline was used in the synthesis of:

• N-[2-hydroxy-1-naphthylidene]-3, 5-bis(trifluoromethyl)aniline, Schiff′s base
• 5,7-bis(trifluoromethyl)aniline
• N-1-phenylethyl-3,5-bis(trifluoromethyl)aniline via titanium-catalyzed hydroamination reaction
• N,N′-bis[3,5-bis(tri-fluoromethyl)phenyl]thiourea, organocatalyst

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 208.4 °F - closed cup
• flash_point_c: 98 °C - closed cup
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter