189898

Methylmagnesium bromide solution

3.0 M in diethyl ether

• Synonym(s): Bromomethylmagnesium
• Linear Formula: CH₃MgBr
• CAS Number: 75-16-1
• Molecular Weight: 119.24
• Beilstein/REAXYS Number: 3535220
• MDL number: MFCD00000041
• UNSPSC Code: 12352111
• PubChem Substance ID: 24851403
• NACRES: NA.22

Properties

• Quality Level: 200
• reaction suitability: reaction type: Grignard Reaction
• concentration: 3.0 M in diethyl ether
• density: 1.035 g/mL at 25 °C
• SMILES string: C[Mg]Br
• InChI: 1S/CH3.BrH.Mg/h1H3;1H;/q;;+1/p-1
• InChI key: AVFUHBJCUUTGCD-UHFFFAOYSA-M

Description

General description

Methylmagnesium bromide solution, also known as bromomethylmagnesium, is both a Lewis acid and nucleophile. It is commonly used as a grignard reagent in organic synthesis reactions.

Application

Methylmagnesium bromide solution (3M in diethyl ether) is used to synthesize:

• 3S-(Boc-amino)-2,4-dimethyl-2-pentanol and methyl tert-butyl (S)-sulfoxide.
• Methyl potassium polyimide (K-PIM-1) (MeMgBr).
• 3(4R)-{3(2R,3S)-[4′-(1′-triphenylmethyl)imidazole]-2-bromo-1-oxobutyl)-4-phenyl2-oxazolidinone
• Benzyl 2-(2-oxopropyl)piperidine-1-carboxylate
• (R*, R*) 1-[1-(1-phenylethyl)pyrrolidin-2-yl]propan-2-one)

Packaging

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

View returnable container options.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H224,H260,H302,H314,H336
• pcodes: P210 - P231 + P232 - P233 - P280 - P303 + P361 + P353 - P305 + P351 + P338 - P403 + P233
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 1 - Skin Corr. 1B - STOT SE 3 - Water-react 1
• target_organs: Central nervous system
• supp_hazards: EUH019
• Storage Class: 4.3 - Hazardous materials which set free flammable gases upon contact with water
• wgk_germany: WGK 1
• flash_point_f: -40.0 °F - closed cup
• flash_point_c: -40 °C - closed cup