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132063

Sigma-Aldrich

Triethylamine

99%

Synonym(s):

N,N-Diethylethanamine

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About This Item

EC Number:
204-469-4
UNSPSC Code:
12352200
Pricing and availability is not currently available.

assay

99%

form

liquid

solubility

water: soluble 112 g/L at 20 °C

General description

Triethylamine trihydrofluoride is a non-corrosive reagent.[1] It is a promising source of fluorine and is widely employed in various benzylic fluorination reactions.[2]

Application

Triethylamine trihydrofluoride (TREAT-HF) may be employed as a fluorinating reagent for the following studies:
  • Microwave-assisted transformation of dichloromethyl- and trichloromethyl substrates to the corresponding fluoro analogs.[3]
  • Preparation of 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine.[1]
  • Synthesis of various fluorinated compounds.[2]
  • Preparation of fluoroamines.[4]

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

12.2 °F - closed cup

flash_point_c

-11 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
U20060
13416CW
06708CW
01903PV
01730KW

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Wei Liu et al.
Angewandte Chemie (International ed. in English), 52(23), 6024-6027 (2013-04-26)
An efficient protocol for the selective fluorination of benzylic C-H bonds is described. The process is catalyzed by manganese salen complexes and uses nucleophilic fluorine sources, such as triethylamine trihydrofluoride and KF. Reaction rates are sufficiently high (30 min) to
Asymmetric Synthesis of Fluoroamines from Chiral Aziridines.
Park H, et al.
Bull. Korean Chem. Soc., 35, 699-700 (2014)
Improved synthesis of 9-(2, 3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl) adenine (FddA) using triethylamine trihydrofluoride.
Takamatsu S, et al.
Tetrahedron Letters, 42(12), 2321-2324 (2001)
Microwave-assisted aliphatic fluorine-chlorine exchange using triethylamine trihydrofluoride (TREAT-HF).
Kremsner JM, et al.
Tetrahedron Letters, 50(26), 3665-3668 (2009)
Marcus Gry Björklund et al.
Nucleic acids research, 36(4), 1334-1342 (2008-01-12)
DNA microarray technology has evolved dramatically in recent years, and is now a common tool in researchers' portfolios. The scope of the technique has expanded from small-scale studies to extensive studies such as classification of disease states. Technical knowledge regarding

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