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128341

Sigma-Aldrich

Fluoroacetamide

Synonym(s):

NSC 31876

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About This Item

Linear Formula:
FCH2CONH2
CAS Number:
Molecular Weight:
77.06
Beilstein/REAXYS Number:
1739054
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

form

solid

Quality Level

mp

106-108 °C (lit.)

SMILES string

NC(=O)CF

InChI

1S/C2H4FNO/c3-1-2(4)5/h1H2,(H2,4,5)

InChI key

FVTWJXMFYOXOKK-UHFFFAOYSA-N

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General description

Fluoroacetamide is a rodenticide that can be assayed by gas chromatography/mass spectrometry.

Application

Reactant involved in:
  • C-N coupling to amides and nitrogen-containing heterocycles
  • Substitution in aryl triflates

Used in mass databases for screening of pesticide residues via fast liquid chromatography TOF mass spectrometry

pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Xiaowei Zhu et al.
International journal of molecular sciences, 20(11) (2019-06-13)
Cuticular wax is a mixture of very long chain fatty acids (VLCFAs) and their derivatives, which determines vital roles for plant growth. In cabbage, the cuticular wax content of leaf blades is an important trait influencing morphological features of the
U Taitelman et al.
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 6, 228-231 (1983-01-01)
Two cases are reported of severe acute fluoroacetamide poisoning in man, with successful treatment of the life-threatening cardiac arrhythmias by the administration of calcium chloride. The arrhythmias were preceded by prolongation of the QT interval in the ECG. Calcium chloride
Sergey V Kuznetsov et al.
Journal of applied toxicology : JAT, 27(6), 538-550 (2007-03-14)
A study was conducted of acute intoxication of infant and adult Wistar rats with fluoroacetamide (FAA), an inhibitor of oxidative metabolism. FAA was administered orally to adult rats at 1/2 LD(50) and subcutaneously to infant rats at LD(100) or 1/10
Arun K Ghosh et al.
The Journal of organic chemistry, 74(10), 3689-3697 (2009-04-14)
Synthesis and reactivity of N-methoxy-N-methyl-(1,3-benzothiazol-2-ylsulfonyl)fluoroacetamide, a building block for Julia olefination, is reported. This reagent undergoes condensation reactions with aldehydes and cyclic ketones to give alpha-fluorovinyl Weinreb amides. Olefination reactions proceed under mild, DBU-mediated conditions, or in the presence of
P J Kostyniak et al.
Toxicology letters, 22(2), 217-222 (1984-08-01)
2,4-Dinitrofluorobenzene (DNFB) reacts with glutathione to form a stable product similar to that formed with the model glutathione-S-transferase (GST) substrate, 1-chloro-2,4-dinitrobenzene (CDNB). DNFB is approx. 40 times als reactive as CDNB in this chemical reaction. The enzymatic defluorination of DNFB

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