T1126
Thyroglobulin from porcine thyroid gland
powder
Synonym(s):
TG human
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About This Item
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biological source
Porcine thyroid
form
powder
mol wt
~670 kDa
composition
Iodine, ≥0.3%
nitrogen analysis
14.0-17.5% total
technique(s)
protein purification: suitable
ash
≤4%
pI
4.58
UniProt accession no.
storage temp.
−20°C
Gene Information
pig ... TG(100156471)
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Biochem/physiol Actions
Thyroglobulin has been shown to regulate the transcription of iodide porters including sodium iodide symporter and pendrin.
Thyroglobulin is a major protein involved with iodine metabolism. It consists of an iodine-containing protein that is stored in the thyroid gland and is converted into circulating thyroxines when the thyroid is stimulated by TSH (Thyroid Stimulating Hormone) from the pituitary. Thyroglobulin is often used as a carrier protein for the production of antibodies. Its advantage as a carrier protein comes from its large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Other Notes
Electrophoretically heterogeneous.
Preparation Note
When reconstituted in water (20 mg/ml), a turbid solution with some insolubles is observed.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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