This product is stored at 2-8°C in the powder form. This item is quite stable in the original sealed vial and is assigned a retest date of 5 years from the date of quality release. The material may be reconstituted in DMSO or Ethanol at 20 mg/mL. Stock solutions may be stored in aliquots, protected from light, for up to 3 months at -20°.
B7272
4-Bromo-calcium Ionophore A23187
powder
Synonym(s):
4-Bromo-A23187, 4-Bromo-calcimycin
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1 MG
$308.00
About This Item
Empirical Formula (Hill Notation):
C29H36BrN3O6
CAS Number:
Molecular Weight:
602.52
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
form
powder
Quality Level
color
yellow
solubility
ethanol: 20 mg/mL
DMSO: soluble
storage temp.
2-8°C
SMILES string
CNc1c(Br)cc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(O)=O
InChI
1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)/t14-,15-,16-,17-,20-,27+,29+/m1/s1
InChI key
LDXQFZZGVTWFCF-FHYGWRBKSA-N
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Application
4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line.[1] It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells.[2]
Nonfluorescent Ca2+ ionophore that can be used to calibrate the quantitation of cytoplasmic free Ca2+ with fluorescent probes.
Biochem/physiol Actions
4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels.[3]
Other Notes
Analog of calcium ionophore A23187
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Transient elevations of cytosolic free calcium retard subsequent apoptosis in neutrophils in vitro.
Whyte MK, et al.
The Journal of Clinical Investigation, 92(1), 446-455 (1993)
R Martínez-Zaguilán et al.
Journal of cellular physiology, 176(1), 196-205 (1998-06-09)
We investigated whether alterations in the mechanisms involved in intracellular pH (pHin) and intracellular calcium ([Ca2+]in) homeostasis are associated with the metastatic potential of poorly (A375P) and highly (C8161) metastatic human melanoma cells. We monitored pHin and [Ca2+]in simultaneously, using
G A Lnenicka et al.
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In cultured nerve cord explants from the crayfish (Procambarus clarkii), the normal impulse activity levels of growing motor axons determine their response to Ca2+ influx. During depolarization or Ca2+ ionophore application, normally active tonic motor axons continue to grow, whereas
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Hi, I purchased Brom A 23187 B7272, $300 CAS# 76455-48-6. It says ethanol: 20mg/ml and storage temp: 2-8C. Is it correct? How long is it stable at 2-8C? Can I keep the 2-4 mM ethanol solution at -20C? And how long? Shinako
1 answer-
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