S0883

Sulfasalazine

97.0-101.5%

• Synonym(s): 2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid, 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, Salicylazosulfapyridine
• Empirical Formula (Hill Notation): C₁₈H₁₄N₄O₅S
• CAS Number: 599-79-1
• Molecular Weight: 398.39
• Beilstein/REAXYS Number: 356241
• EC Number: 209-974-3
• MDL number: MFCD00057363
• UNSPSC Code: 41116107
• PubChem Substance ID: 329824182
• NACRES: NA.24

Properties

• Quality Level: 200
• assay: 97.0-101.5%
• form: powder
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 260-265 °C (dec.) (lit.)
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• mode of action: DNA synthesis | interferes; enzyme | inhibits
• SMILES string: OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3
• InChI: 1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
• InChI key: NCEXYHBECQHGNR-QZQOTICOSA-N
• Gene Information: human ... ALOX5(240) , PTGS1(5742) , PTGS2(5743)

Description

General description

Chemical structure: sulfonamide

Sulfasalazine (SSZ) belongs to the sulfonamide class of drugs, which can be metabolized into 5-aminosalicylic acid and sulfapyridine. SSZ is obtained as a reaction product of an antibacterial agent (sulfapyridine) and an anti-inflammatory agent (salicylic acid).

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Sulfasalazine has been used as an analytical standard in clinical studies:

• For investigating its therapeutic potential in patients suffering from multiple sclerosis (MS).
• For studying its role as an antiarthritic agent via inhibition of the cartilage degeneration and pain associated with progression of osteoarthritis in the rat, which is used as the test animal.

It may also be used as an analytical reference standard for the quantification of the analyte in biological samples and aqueous samples using enzyme-linked immunosorbent assay (ELISA) and spectrofluorimetic technique.

Safety Information

• pictograms: GHS08,GHS09
• signalword: Danger
• hcodes: H317,H334,H351,H361f,H411
• pcodes: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves