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Key Documents

I19209

Sigma-Aldrich

Isophthalic acid

99%

Synonym(s):

Benzene-1,3-dicarboxylic acid

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About This Item

Linear Formula:
C6H4-1,3-(CO2H)2
CAS Number:
Molecular Weight:
166.13
Beilstein/REAXYS Number:
1909332
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

assay

99%

autoignition temp.

1198 °F

mp

341-343 °C (lit.)

SMILES string

OC(=O)c1cccc(c1)C(O)=O

InChI

1S/C8H6O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h1-4H,(H,9,10)(H,11,12)

InChI key

QQVIHTHCMHWDBS-UHFFFAOYSA-N

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Application

Isophthalic acid can be used as a reactant to prepare:
  • Poly(m-phenyleneisophthalamide) by polycondensation with m-phenylenediamine via thermal solid-phase polymerization reaction.

It can also be used as a ligand to synthesize:
  • Metal coordination polymers by hydrothermal and sonochemical process.
  • Isophthalic acid-zirconium(IV) nanocomposite, which is used as a precursor to prepare crystalline tetragonal ZrO2 via thermal decomposition method.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Isabela M Aparicio et al.
Molecular and biochemical parasitology, 172(2), 152-155 (2010-04-20)
With the rapid spread of drug-resistant strains of Plasmodium falciparum, the development of new antimalarials is an urgent need. As malaria parasites live in a highly pro-oxidant environment, their anti-oxidant defences have frequently been suggested as candidate drug targets. A
Synthesis of poly (m-phenyleneisophthalamide) by solid-state polycondensation of isophthalic acid with m-phenylenediamine
Zhang C, et al.
Journal of Polymer Science Part A: Polymer Chemistry, 49(22), 4725-4728 (2011)
Zafer Üstündağ et al.
The Analyst, 136(7), 1464-1471 (2011-02-16)
The scope of this study is to modify a Surface Plasmon Resonance (SPR) sensor slide with isophthalic acid to evaluate the possible application on the detection of copper(II) ions in aqueous media by total internal reflection ellipsometry. A gold sensor
Taleb H Al-Tel et al.
Journal of medicinal chemistry, 52(20), 6484-6488 (2009-10-01)
We have identified small-molecule dibenzazepine inhibitors of beta-secretase (BACE1). These BACE1 inhibitors possess two key salient features. The first is a seven-membered heterocyclic ring fused to two aromatic rings representing the P3-P2 residues. The second is an amide and/or amide
Jarrod F Eubank et al.
Journal of the American Chemical Society, 133(44), 17532-17535 (2011-06-17)
A new pillaring strategy, based on a ligand-to-axial approach that combines the two previous common techniques, axial-to-axial and ligand-to-ligand, and permits design, access, and construction of higher dimensional MOFs, is introduced and validated. Trigonal heterofunctional ligands, in this case isophthalic

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