- The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.
Nature communications (2016-11-25)
Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac, Anne Eichmann
PMID27882935
摘要
Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4