跳轉至內容

Surface charge switching nanoparticles for magnetic resonance imaging.

Surface charge switching nanoparticles for magnetic resonance imaging.

International journal of pharmaceutics (2014-05-27)

Dong Jin Lee, Young Taik Oh, Eun Seong Lee

摘要

In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in vitro cellular uptake and high accumulation in the acidic tumor site in vivo. Consequently, Fe3O4-loaded nanoparticles enabled high contrast magnetic resonance (MR) imaging of the tumor in vivo.

材料

產品編號

品牌

產品描述

Sigma-Aldrich

二甲基亚砜, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

Sigma-Aldrich

二甲基亚砜, ACS reagent, ≥99.9%

Sigma-Aldrich

三氟乙酸, ReagentPlus^®, 99%

Sigma-Aldrich

三氟乙酸, suitable for HPLC, ≥99.0%

Sigma-Aldrich

二甲基亚砜, for molecular biology

Sigma-Aldrich

乙酸, glacial, ACS reagent, ≥99.7%

Sigma-Aldrich

二甲基亚砜, suitable for HPLC, ≥99.7%

Sigma-Aldrich

N,N-二甲基甲酰胺, ACS reagent, ≥99.8%

Sigma-Aldrich

二甲基亚砜, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

Sigma-Aldrich

N,N-二甲基甲酰胺, suitable for HPLC, ≥99.9%

Sigma-Aldrich

乙酸, glacial, ReagentPlus^®, ≥99%

Sigma-Aldrich

二乙醚, anhydrous, ACS reagent, ≥99.0%, contains BHT as inhibitor

Sigma-Aldrich

二甲基亚砜, ReagentPlus^®, ≥99.5%

Sigma-Aldrich

吡啶, ACS reagent, ≥99.0%

Sigma-Aldrich

二乙醚, suitable for HPLC, ≥99.9%, inhibitor-free

Sigma-Aldrich

正己烷, suitable for HPLC, ≥97.0% (GC)

Sigma-Aldrich

二乙醚, ACS reagent, anhydrous, ≥99.0%, contains BHT as inhibitor

Sigma-Aldrich

三氟乙酸, puriss. p.a., suitable for HPLC, ≥99.0% (GC)

Sigma-Aldrich

正己烷, ReagentPlus^®, ≥99%

Sigma-Aldrich

正己烷, suitable for HPLC, ≥95%

Sigma-Aldrich

二甲基亚砜, ≥99.5% (GC), suitable for plant cell culture

Sigma-Aldrich

二甲基亚砜, puriss. p.a., ACS reagent, ≥99.9% (GC)

Sigma-Aldrich

吡啶, suitable for HPLC, ≥99.9%

Sigma-Aldrich

N-羟基丁二酰亚胺, 98%

Sigma-Aldrich

乙酸, glacial, ≥99.99% trace metals basis

Sigma-Aldrich

正己烷, Laboratory Reagent, ≥95%

Sigma-Aldrich

正己烷, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99% (GC)

Sigma-Aldrich

乙酸溶液, suitable for HPLC

Sigma-Aldrich

正己烷, HPLC Plus, for HPLC, GC, and residue analysis, ≥95%

Sigma-Aldrich

乙酸, glacial, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, 99.8-100.5%