跳轉至內容

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

摘要

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

材料

產品編號

品牌

產品描述

Sigma-Aldrich

Raney^®-镍, W.R. Grace and Co. Raney^® 2800, slurry, in H₂O, active catalyst

Sigma-Aldrich

镍, nanopowder, <100 nm avg. part. size, ≥99% trace metals basis

Sigma-Aldrich

钴, powder, 2 μm particle size, 99.8% trace metals basis

Sigma-Aldrich

Raney^®-镍, W.R. Grace and Co. Raney^® 2400, slurry, in H₂O, active catalyst

Sigma-Aldrich

镍, powder, <50 μm, 99.7% trace metals basis

Sigma-Aldrich

镍, powder, <150 μm, 99.99% trace metals basis

Sigma-Aldrich

钴, powder, <150 μm, ≥99.9% trace metals basis

Sigma-Aldrich

镍, foil, thickness 0.125 mm, ≥99.9%

Sigma-Aldrich

Raney^®-镍, W.R. Grace and Co. Raney^® 4200, slurry, in H₂O, active catalyst

Sigma-Aldrich

镍, wire, diam. 0.25 mm, ≥99.9%

Sigma-Aldrich

钴, granular, 99.99% trace metals basis

Sigma-Aldrich

镍, powder, <1 μm, 99.8% trace metals basis

Sigma-Aldrich

镍, foil, thickness 0.5 mm, 99.98% trace metals basis

Sigma-Aldrich

Raney^®-镍, W.R. Grace and Co. Raney^® 3202, slurry, in H₂O, active catalyst

Sigma-Aldrich

镍, foil, thickness 0.25 mm, 99.995% trace metals basis

Sigma-Aldrich

钴, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%

Sigma-Aldrich

镍, foil, thickness 0.1 mm, 99.98% trace metals basis

Sigma-Aldrich

钴, pieces, 99.5% trace metals basis

Sigma-Aldrich

镍, rod, diam. 6.35 mm, ≥99.99% trace metals basis

Sigma-Aldrich

钴, foil, thickness 0.1 mm, 99.95% trace metals basis

Sigma-Aldrich

钴, rod, diam. 5.0 mm, 99.95% trace metals basis

Sigma-Aldrich

镍, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.95% trace metals basis

Sigma-Aldrich

钴, wire, diam. 1.0 mm, 99.995% trace metals basis

Sigma-Aldrich

镍, wire, diam. 0.5 mm, ≥99.99% trace metals basis

Sigma-Aldrich

镍, wire, diam. 0.5 mm, ≥99.9% trace metals basis

Sigma-Aldrich

钴, foil, thickness 1.0 mm, 99.95% trace metals basis

Sigma-Aldrich

钴, foil, thickness 0.1 mm, ≥99.99%

镍, wire reel, 1m, diameter 1.0mm, as drawn, 99%