Efficient metal-free synthesis of various pyrido[2',1':2,3]imidazo- [4,5-b]quinolines.

Efficient metal-free synthesis of various pyrido[2',1':2,3]imidazo- [4,5-b]quinolines.

Chemistry (Weinheim an der Bergstrasse, Germany) (2013-08-21)

Mathieu Arnould, Marie-Aude Hiebel, Stéphane Massip, Jean Michel Léger, Christian Jarry, Sabine Berteina-Raboin, Gérald Guillaumet

PMID23955568

摘要

Dancing with diversity: The synthesis of diverse pyrido[2',1':2,3]imidazo[4,5-b]quinolines bearing several substitution patterns was developed based on combining a multicomponent reaction (Groebke-Blackburn-Bienaymé reaction) with an original cyclization as a secondary transformation (see scheme; DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).

材料

產品編號

品牌

產品描述

139009

Sigma-Aldrich

1,8-二氮杂双环[5.4.0]十一碳-7-烯, 98%

33482

Sigma-Aldrich

1,8-二氮杂双环[5.4.0]十一碳-7-烯, puriss., ≥99.0% (GC)

714852

Sigma-Aldrich

1,8-二氮杂双环[5.4.0]十一碳-7-烯溶液, 1 M in THF