跳轉至內容
Merck
  • Hydroxypropyl methyl cellulose grafted with polyacrylamide: application in controlled release of 5-amino salicylic acid.

Hydroxypropyl methyl cellulose grafted with polyacrylamide: application in controlled release of 5-amino salicylic acid.

Colloids and surfaces. B, Biointerfaces (2013-06-05)
Raghunath Das, Sagar Pal
摘要

In the present study, hydroxypropyl methyl cellulose grafted with polyacrylamide (HPMC-g-PAM) hydrogel was evaluated in vitro as a potential carrier for controlled release of 5-amino salicylic acid (5-ASA). The graft copolymer was developed by grafting PAM chains onto HPMC backbone using potassium persulphate as initiator. The swelling behaviour of hydrogel based tablet was investigated as a function of pH and time in various buffer solutions similar to that of gastric and intestinal fluids. The % equilibrium swelling was found to be higher in case of simulated intestinal fluid (pH=7.4) and lower in simulated gastric fluid (pH=1.2), making an ideal matrix as required for colon specific drug delivery. The drug release study was performed at various pH values akin to the condition of GI tract. The release kinetics of 5-ASA showed non-Fickian diffusion behaviour. This indicates that the release is controlled by a combination of polymer relaxation or erosion of the matrix and diffusion of the drug from the swollen matrix.

材料
產品編號
品牌
產品描述

Sigma-Aldrich
甲基纤维素, viscosity: 4,000 cP
Sigma-Aldrich
羟丙基 甲基纤维素, viscosity 2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)
Sigma-Aldrich
甲基纤维素, viscosity: 15 cP, BioReagent, suitable for cell culture
Sigma-Aldrich
甲基纤维素, viscosity: 1,500 cP
Sigma-Aldrich
羟丙基 甲基纤维素
Sigma-Aldrich
羟丙基 甲基纤维素, average Mn ~10,000
Sigma-Aldrich
甲基纤维素, viscosity: 15 cP
Sigma-Aldrich
羟丙基 甲基纤维素, viscosity 40-60 cP, 2 % in H2O(20 °C)(lit.)
Sigma-Aldrich
羟丙基 甲基纤维素, viscosity 80-120 cP, 2 % in H2O(20 °C)(lit.)
Sigma-Aldrich
羟丙基 甲基纤维素, average Mn ~86,000
Sigma-Aldrich
羟丙基 甲基纤维素, average Mn ~120,000
Sigma-Aldrich
甲基纤维素, viscosity: 25 cP
Sigma-Aldrich
5-氨基水杨酸, ≥99%
Sigma-Aldrich
羟丙基 甲基纤维素, average Mn ~90,000
Sigma-Aldrich
5-氨基水杨酸, 95%
Sigma-Aldrich
羟丙甲纤维素, meets USP testing specifications
Sigma-Aldrich
甲基纤维素, 27.5-31.5% (Methoxyl content), viscosity: 400 cP
Sigma-Aldrich
Methocel® A15 LV, 27.5-31.5% methoxyl basis
Sigma-Aldrich
Methocel® A4M, viscosity 3000-5500 mPa.s, 2 % in H2O(20 °C)
Supelco
氨水杨酸, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
甲基纤维素, meets USP testing specifications, 26.0-33.0% (methoxyl group, on Dry Basis), viscosity: 400 cP
Sigma-Aldrich
Methocel® A15C, medium viscosity, Methoxyl content 27.5-31.5 %
Sigma-Aldrich
甲基纤维素, 26.0-33.0% (Methoxy group (dry basis)), meets USP testing specifications, viscosity: 1,500 cP
Sigma-Aldrich
甲基纤维素, tested according to Ph. Eur.