UC214

(S)-(−)-华法林

≥97% (HPLC)

• 同義詞: S-(−)-3-Acetonybenzyl)-4-hydroxycoumarin, S-(−)-4-Hydroxy-3-(3-oxo-1-phenybutyl)-2H-1-benzopyran-2-one
• 經驗公式（希爾表示法）: C₁₉H₁₆O₄
• CAS號碼: 5543-57-7
• 分子量：: 308.33
• EC號碼: 226-907-3
• MDL號碼: MFCD00272381
• 分類程式碼代碼: 12161501
• PubChem物質ID: 24724650
• NACRES: NA.77

屬性

• 化驗: ≥97% (HPLC)
• 形狀: solid
• 顏色: white to pale yellow
• mp: ≥170 °C
• 儲存溫度: 2-8°C
• SMILES 字串: [H][C@](CC(C)=O)(c1ccccc1)C2=C(O)c3ccccc3OC2=O
• InChI: 1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3/t15-/m0/s1
• InChI 密鑰: PJVWKTKQMONHTI-HNNXBMFYSA-N
• 基因資訊: human ... CYP2C9(1559)

描述

一般說明

Warfarin is an antagonist of vitamin K. It is an oral coumarin anticoagulant.

應用

(S)-(−)-Warfarin has been used in cell cultures.

Studies using (R)-(+)-warfarin have reported that it can upregulate hepatic CYP3A4 and CYP2C. It has also been used in HepG2 cells to study protein profiles.

生化／生理作用

Warfarin is used to regulate and inhibit thromboembolic disorders. The CYP2C9 (cytochrome P450 family 2 subfamily C member 9) protein plays a major role in the inactivation of potent S-warfarin.

CYP2C9 substrate; anticoagulant.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

安全資訊

• 象形圖: GHS06,GHS08,GHS09
• 訊號詞: Danger
• 危險聲明: H300 + H310 + H330,H360D,H372,H411
• 防範說明: P202 - P264 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• 危險分類: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Repr. 1A - STOT RE 1
• 標靶器官: Blood
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable