推薦產品
形狀
solid
顏色
white
mp
153-154 °C
儲存溫度
2-8°C
SMILES 字串
CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2
InChI
1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)
InChI 密鑰
OQPLORUDZLXXPD-UHFFFAOYSA-N
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一般說明
美芬妥英的 YP2C19 代谢物。
應用
4-羟基苯乙妥英已被用于开发超高效液相色谱(UPLC)-串联质谱分析(MS/MS),以评估人尿或血浆样品中的细胞色素P450(CYP)探针药物及其相关代谢产物。4-羟基苯乙妥英还被用于开发一类基于亚2微米颗粒LC/MS/MS的方法来分析CYP450探针底物代谢产物。
生化/生理作用
4-羟基苯乙妥英分解代谢显示出了遗传多态性,并是细胞色素P450 2C19(CYP2C19)活性的一种直接指示剂。通过高效液相色谱对生物样品中4-羟基苯乙妥英的检测和定量已被充分的优化。
包裝
无底玻璃瓶。内含物在插入的融合锥体内。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。
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The efficiency of drug metabolism by a single enzyme can be measured as the fractional metabolic clearance which can be used as a measure of whole body activity for that enzyme. Measurement of activity of multiple enzymes simultaneously is feasible
Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test
Journal of Chromatography. B, Biomedical Sciences and Applications, 676(1), 87-94 (1996)
Rapid communications in mass spectrometry : RCM, 22(9), 1345-1350 (2008-04-03)
The measurement of cytochrome P450 (CYP450) isoenzyme inhibition is often done during evaluation of new chemical entities in drug discovery. Typical assay protocol consists of multiple CYP450 probe substrates incubated with selected drug candidates and CYP450. Results of the assay
High-performance liquid chromatographic determination of urinary 4?-hydroxymephenytoin, a metabolic marker for the hepatic enzyme CYP2C19, in humans
Journal of Chromatography. B, Biomedical Sciences and Applications, 668(1), 125-131 (1995)
Journal of chromatography. B, Biomedical applications, 668(1), 125-131 (1995-06-09)
The preferential hydroxylation of (S)-mephenytoin to 4'-hydroxymephenytoin (4'-OH-M) displays a genetic polymorphism of drug metabolism in humans. Thus the excreted 4'-OH-M is considered to be an important marker for the hepatic (S)-mephenytoin 4'-hydroxylase. Accordingly, a mixture of urine containing total
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