T9702

Anti-p8/TTD-A (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• 同義詞: Anti-C6orf175 TFB5, Anti-Chromosome 6 open reading frame 175, Anti-GTF2H5, Anti-General transcription factor IIH, polypeptide 5, Anti-TFIIH basal transcription factor complex, TTDA subunit, Anti-TGF2H5, Anti-TTDA transcription factor IIH, 8-kd subunit
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~35 kDa (tagged fused protein)
• 物種活性: mouse, rat, human
• 加強驗證: recombinant expression; Learn more about Antibody Enhanced Validation
• 濃度: ~1 mg/mL
• 技術: indirect immunofluorescence: 5-10 μg/mL using paraformaldehyde-fixed HEK-293T cells over-expressing human p8/TTD-A; western blot: 1-2 μg/mL using HEK-293T over-expressing human p8/TTD-A
• UniProt登錄號: Q6ZYL4
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... GTF2H5(404672) ; mouse ... Gtf2H5(66467) ; rat ... Gtf2h5(502227)

描述

一般說明

8-kDa trichothiodystrophy group A (p8/TTD-A) protein is the tenth subunit of general transcription factor IIH (TGFIIH). This protein exists as attached to transcription factor IIH (TFIIH) and as a free fraction that alternates between the cytoplasm and nucleus. p8/TTD-A gene is mapped on the human chromosome at 6q25.3.

特異性

Anti-p8/TTD-A (C-terminal) specifically recognizes human, rat, and mouse p8/TTD-A.

應用

Anti-p8/TTD-A (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunofluorescence.

生化／生理作用

8-kDa trichothiodystrophy group A (p8/TTD-A) protein defects leads to a sun-sensitive form of trichothiodystrophy (TTD), a rare autosomal recessive disorder. It is essential for the stability of the transcription factor IIH (TFIIH) complex. The cells from patients with p8/TTD-A have reduced levels of TFIIH while overexpressing p8/TTD-A restored the cellular level TFIIH complex.

標靶描述

p8/TTD-A (C-terminal) encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and is implicated in regulating

外觀

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

儲存和穩定性

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)