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Merck
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重要文件

T9514

Sigma-Aldrich

Tetrahydropapaverine hydrochloride

≥90%, powder

同義詞:

6,7-Dimethoxy-1-(3,4-dimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline

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About This Item

經驗公式(希爾表示法):
C20H25NO4 · HCl
CAS號碼:
分子量::
379.88
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200

化驗

≥90%

形狀

powder

顏色

white

溶解度

H2O: soluble

儲存溫度

2-8°C

SMILES 字串

Cl.COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC

生化/生理作用

Phosphodiesterase inhibitor.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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S Hosztafi et al.
Pharmacological research, 32(1-2), 15-20 (1995-07-01)
This review surveys the discovery of endogenous alkaloids in mammals. The formation of morphine in mammalian brain was assumed in 1970. The existence of morphine was demonstrated by radioimmunoassay. Identification of morphine was performed by spectroscopic methods. The isolation of
I Koshimura et al.
Brain research, 773(1-2), 108-116 (1997-12-31)
We report the toxic effects of 3,4-dimethoxyphenylethylamine (DMPEA), and tetrahydropapaverine (THP) on the rat nigrostriatal system; THP is a tetrahydroisoquinoline compound which may be derived from DMPEA by conjugation of DMPEA and its oxidative metabolite, dimethoxyphenylacetaldehyde; both are potent inhibitors
Eung Il Kim et al.
Life sciences, 75(16), 1949-1957 (2004-08-13)
The inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells were investigated. Tetrahydropapaverine at concentration ranges of 5-20 microM decreased serotonin content in a concentration-dependent manner in P815 cells and showed 42.1% inhibition of serotonin content
S Chulia et al.
British journal of pharmacology, 122(3), 409-416 (1997-11-14)
1. In the present work, the properties of 3-methyl isoquinoline, 3,4-dihydropapaverine, tetrahydropapaverine and tetrahydropapaveroline were compared with those of papaverine and laudanosine. The work includes functional studies on rat isolated aorta contracted with noradrenaline, caffeine or KCl, and a determination
K Suzuki et al.
Advances in neurology, 53, 215-218 (1990-01-01)
Effects of MPTP-like compounds on mitochondrial respiration, activity of NADH-ubiquinone oxidoreductase (complex I) and on ATP synthesis were reported. Mitochondria prepared from mouse whole brains were used. The compounds tested include tetrahydroisoquinoline (TIQ), tetrahydropapaveroline (THP), tetrahydropapaverine (THPV), and salsolinol. TIQ

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