T8024

河鲀毒素

≥98% (HPLC), powder

• 同義詞: Fugu poison, Maculotoxin, TTX, Tarichatoxin
• 經驗公式（希爾表示法）: C₁₁H₁₇N₃O₈
• CAS號碼: 4368-28-9
• 分子量：: 319.27
• Beilstein: 49176
• EC號碼: 224-458-8
• MDL號碼: MFCD00213719
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24900493

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white
• 溶解度: dilute citrate or acetate buffer: 1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.); strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
• 儲存溫度: 2-8°C
• SMILES 字串: [H][C@]12OC3(O)OC(C4[C@@H](O)NC(=N)NC4([C@@H]1O)[C@@H]3O)[C@@]2(O)CO
• InChI: 1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1
• InChI 密鑰: CFMYXEVWODSLAX-IXUBDLNJSA-N
• 基因資訊: rat ... Scnn1g(24768)

描述

應用

Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N). Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca²⁺ currents in rat hippocampal interneurons.

生化／生理作用

Reversible, selective blocker of Na⁺ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

準備報告

Tetrodotoxin is soluble in dilute citrate or acetate buffer at 1 mg/ml (pH 4-5). Aqueous solutions are stable at pH 4-5 if stored frozen. However, tetrodotoxin is unstable in strong acid or alkaline solutions and is destroyed by boiling at pH2.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300
• 防範說明: P301 + P330 + P331 + P310
• 危險分類: Acute Tox. 1 Oral
• 儲存類別代碼: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges