化驗
≥98%
形狀
powder
溶解度
methylene chloride: soluble 10 mg/mL
DMSO: soluble
儲存溫度
2-8°C
SMILES 字串
COc1cc2ncc(nc2cc1OC)-c3ccccc3
InChI
1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3
InChI 密鑰
QNOXYUNHIGOWNY-UHFFFAOYSA-N
生化／生理作用
Studies have reported that phosphorylation of tyrosine 857 in PDGF β-receptor is the most susceptible to inhibition by tyrphostin AG 12962.
Selective inhibitor of platelet-derived growth factor (PDGF) receptor protein.
準備報告
Tyrphostin AG 1296 is soluble in methylene chloride at 10 mg/ml and is also soluble in DMSO.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Pascale Piednoir et al.
Critical care medicine, 40(7), 2041-2049 (2012-06-21)
Fibroblast migration is an initiating step in fibroproliferation; its involvement during acute lung injury and acute respiratory distress syndrome remains poorly understood. The aims of this study were: 1) to determine whether bronchoalveolar lavage fluids from patients with acute lung
Kate Chao-Wei Chen et al.
Molecular vision, 13, 374-387 (2007-03-30)
The mitogenic action of PDGF has been shown to associate with reactive oxygen species (ROS) generation, but the mechanism leading to ROS production and subsequent cell proliferation is not clear. We investigated the upstream membrane-bound target proteins involved in PDGF-stimulated
Gudrun Reiterer et al.
Cancer research, 67(16), 7765-7772 (2007-08-19)
Here, we show that the platelet-derived growth factor receptor (PDGFR) regulates myeloid and monocytic differentiation of HL-60 myeloblastic leukemia cells in response to retinoic acid (RA) and vitamin D3 (D3), respectively. Both RA and D3 decreased the expression of PDGFR-alpha
Silvia Svegliati Baroni et al.
The New England journal of medicine, 354(25), 2667-2676 (2006-06-23)
Systemic sclerosis (scleroderma) is characterized by immunologic abnormalities, injury of endothelial cells, and tissue fibrosis. Abnormal oxidative stress has been documented in scleroderma and linked to fibroblast activation. Since platelet-derived growth factor (PDGF) stimulates the production of reactive oxygen species
U Mony et al.
Leukemia, 22(7), 1395-1401 (2008-05-30)
Relapse in acute myeloid leukaemia (AML) is mediated by survival of leukaemic stem cells following remission-induction chemotherapy. It would therefore be useful to identify therapeutic agents that target leukaemic stem cells. We devised a flow cytometric chemosensitivity assay allowing 48
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