SRP6456

EPHB4 human

recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)

• 同義詞: Ephrin-type-B-receptor-4, HTK, MYK1, TYRO11
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: human
• 重組細胞: expressed in HEK 293 cells
• 籤條: 6-His tagged (C-terminus)
• 化驗: ≥97% (SDS-PAGE)
• 形狀: lyophilized
• 分子量: calculated mol wt 57.8 kDa; observed mol wt 65-70 kDa by SDS-PAGE (DTT- reduced.)
• 包裝: pkg of 20 and 100 μg
• 雜質: <1 EU/μg endotoxin (LAL test)
• UniProt登錄號: P54760
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... EPHB4(2050)

描述

一般說明

Ephrin type-B receptor 4 (EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. In contrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.

外觀

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重構

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable