SRP6431

ICOSLG/B7-H2/CD275 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

• 同義詞: B7H2, B7RP-1, B7RP1, GL50, ICOS ligand, ICOS-L, ICOSL, LICOS
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: human
• 重組細胞: expressed in HEK 293 cells
• 籤條: 6-His tagged (C-terminus)
• 化驗: ≥95% (SDS-PAGE)
• 形狀: lyophilized
• 效力: 3.2-400 ng/mL
• 分子量: calculated mol wt 27.5 kDa; observed mol wt 45-50 kDa (DTT-reduced. Protein migrates due to glycosylation. Asp 19 is the predicted N-terminal.)
• 包裝: pkg of 20 and 100 μg
• 雜質: <1 EU/μg
• UniProt登錄號: O75144
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... ICOSLG(23308)

描述

一般說明

ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.

外觀

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重構

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable