SRP6212

sDLL-1 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

• 同義詞: Delta-1, Delta-like protein 1
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: human
• 重組細胞: expressed in HEK 293 cells
• 化驗: ≥95% (SDS-PAGE)
• 形狀: lyophilized powder
• 分子量: 57-60 kDa
• 包裝: pkg of 10 μg; pkg of 50 μg
• 雜質: <1 EU/μg endotoxin (LAL test)
• UniProt登錄號: O00548
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... DLL-1(28514)

描述

一般說明

Human sDLL-1 comprises the extracellular signaling domain of DLL-1, a member of a structurally-related family of single-pass type I transmembrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. Recombinant human sDLL-1 is a 57.0-60.0 kDa glycoprotein containing 522 amino-acid residues. The DLL-1 gene is mapped to human chromosome 6q27.

生化／生理作用

DLL-1 (delta-like ligand 1) functions to specifically activate the Notch-1 and Notch-2 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. DLL-1 suppresses differentiation of hematopoietic progenitor cells into the B-cell lineage while promoting differentiation to T-cell and NK (natural killer) cell precursors. Upregulation of DLL-1 was observed in choriocarcinoma and hepatocellular carcinoma.

外觀

Sterile filtered through a 0.2 micron filter. Lyophilized from 1X PBS, pH 7.5.

重構

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

安全資訊

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable