推薦產品
生物源
mouse
重組細胞
expressed in E. coli
化驗
≥95% (HPLC)
≥95% (SDS-PAGE)
形狀
lyophilized
效力
≥1x10^6 units/mg
分子量
9.8 kDa
包裝
pkg of 10 μg
雜質
≤1 EU/μg
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... HBEGF(15200)
一般說明
HB-EGF (heparin-binding epidermal growth factor-like growth factor) belongs to the EGF family, and was first isolated as a secreted product from cultured human macrophages. It is produced as a precursor transmembrane protein (pro-HB-EGF), which is composed of EGF-like and heparin-binding domains. This precursor protein can be cleaved to produce a mature and soluble HB-EGF (sHB-EGF) form, and both these forms are active. It is expressed in various cell types including endothelial cells, epithelial cells, hematopoietic cells, and vascular smooth muscle cells.
生化／生理作用
HB-EGF (heparin-binding epidermal growth factor-like growth factor) functions as a mitogen and a chemotactic factor. Studies in experimental necrotizing enterocolitis (NEC) show that enteral administration of this factor confers protection to intestines from tissue injury, facilitates migration and proliferation of enterocytes, and maintains intestinal stem cell (ISC) viability. In endothelial nitric oxide synthase (eNOS)-knockout mice, a reduction in nitric oxide bioavailability results in elevated HB-EGF expression, which might be play an important role in progressive diabetic nephropathy. In mice with inactivated HB-EGF gene in the hippocampal area, there is reduced neurogenesis in the subgranular zone (SGZ) of the dentate gyrus. These mice also show suppression of PSD-95 (post synaptic density)/NMDA (N-methyl-D-aspartate)-receptor-NR1 (NMDA receptor)/NR2B subunits, and the subsequent NMDA receptor signaling.
外觀
Lyophilized with no additives
準備報告
Centrifuge the vial prior to opening.
重構
It is recommended to reconstitute the lyophilized Mouse HB-EGF in sterile 18M-cm H?O not less than 100 μg/mL, which can then be further diluted to other aqueous solutions.
其他說明
DLEGTDLNLF KVAFSSKPQG LATPSKERNG KKKKKGKGLG KKRDPCLRKY KDYCIHGECR YLQEFRTPSC KCLPGYHGHR CHGLTL.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Heparin-binding EGF-like growth factor and enteric neural stem cell transplantation in the prevention of experimental necrotizing enterocolitis in mice.
Wei J, et al.
Pediatric Research, 78(1), 29-37 (2015)
NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice.
Sasaki K, et al.
Molecular Brain, 8(1) (2015)
Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression.
Miyazawa T, et al.
Kidney International, 84(6), 1176-1188 (2013)
Simon Melderis et al.
Journal of the American Society of Nephrology : JASN, 31(9), 1996-2012 (2020-07-04)
Recent studies have identified the EGF receptor (EGFR) ligand amphiregulin (AREG) as an important mediator of inflammatory diseases. Both pro- and anti-inflammatory functions have been described, but the role of AREG in GN remains unknown. The nephrotoxic nephritis model of
Nelson Ung et al.
Cancer biology & therapy, 15(5), 623-632 (2014-02-22)
Several agents targeting the epidermal growth factor receptor (EGFR) have been FDA-approved to treat cancer patients with varying tumor types including metastatic colorectal cancer. Many patients treated with anti-EGFR therapy however do not respond and those that do initially respond
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務