SRP4542

FGF-19 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• 同義詞: FGF19, FGFJ, fibroblast growth factor 19
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 生物源: human
• 重組細胞: expressed in E. coli
• 化驗: ≥95% (SDS-PAGE)
• 形狀: lyophilized
• 效力: 50-200 ng/mL
• 分子量: ~21.8 kDa
• 包裝: pkg of 25 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 雜質: endotoxin, tested
• NCBI登錄號: NM_005117
• UniProt登錄號: O95750
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... FGF19(9965)

描述

一般說明

Fibroblast growth factor-19 (FGF-19) is an ileum-derived polypeptide hormone and a high affinity heparin-dependent ligand for fibroblast growth factor receptor 4 (FGFR4). It is part of the hormone-like FGF family. The gene encoding FGF-19 is localized on human chromosome 11q13.3. Recombinant human FGF-19 is a 21.8kDa protein containing 195 amino acid residues.

生化／生理作用

Fibroblast growth factor-19 (FGF-19) is involved in the gut-liver signaling pathway and modulation of bile acid synthesis. Once secreted, it binds to the hepatic fibroblast growth factor receptor 4 (FGFR4)/Klotho-β cell-surface receptor complex and activates it. FGF-19 promotes glycogen synthesis, protein synthesis and lipid metabolism.

外觀

Lyophilized from 5 mM Tris, pH 7.6 plus 75 mM NaCl. The protein may appear as a haze or film, which you may not see at the bottom of the vial.

重構

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1 to 1.0 μg/μL. This solution can then be diluted into other aqueous buffers.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable