生物源
human
重組細胞
expressed in insect cells
化驗
≥80% (SDS-PAGE)
形狀
frozen liquid
分子量
~68 kDa
包裝
pkg of 4 μg
儲存條件
avoid repeated freeze/thaw cycles
濃度
200 μg/mL
顏色
colorless to clear
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... ESR1(2099)
一般說明
The gene ESR1 (estrogen receptor-alpha) encodes a member of the superfamily of nuclear hormone receptors that are essential for the functioning of female reproductive system. The gene is mapped to human chromosome 6q25.
生化／生理作用
Several members of the nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor alpha (RAR alpha) in acute promyelocytic leukemia. Estrogen receptors (ER) are members of the superfamily of nuclear hormone receptors (2, 3) whose activity is required for the normal function of the female reproductive system. Two isoforms of estrogen receptor (ER α and ER β) have been described. They function as ligand-dependent transcriptional activators. The biological functions downstream of ER result from altered expression of direct transcriptional targets as well as secondary effects mediated by biological activities of direct targets. In the mammary gland, estrogen receptors regulate normal epithelial cell development and differentiation through their well-documented effects on transcription. Estrogens have long been known to have mitogenic functions in breast cancer cell lines and in breast tumors. Selective estrogen receptor modulatory compounds (SERMs), which bind directly to ER, can block the growth stimulatory function of estrogens.
外觀
Clear and colorless frozen liquid solution
準備報告
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer.
Holst F
Nature Genetics, 39, 655-660 (2007)
Activating ESR1 mutations in hormone-resistant metastatic breast cancer.
Robinson DR
Nature Genetics, 45, 1446-1451 (2013)
Hyo Jin Gim et al.
European journal of medicinal chemistry, 85, 107-118 (2014-08-01)
A series of azaisoflavone analogs were designed and synthesized and their transactivation activities and binding affinities for ERα and ERβ were investigated. Among these compounds, 2b and 3a were the most potent with 6.5 and 1.1 μM of EC50, respectively. Molecular
Molecular mechanisms of action of steroid/thyroid receptor superfamily members.
M J Tsai et al.
Annual review of biochemistry, 63, 451-486 (1994-01-01)
Juan-Juan Yin et al.
International journal of nanomedicine, 10, 4717-4730 (2015-08-08)
Breast cancer is a leading killer of women worldwide. Cyclodextrin-based estrogen receptor-targeting drug-delivery systems represent a promising direction in cancer therapy but have rarely been investigated. To seek new targeting therapies for membrane estrogen receptor-positive breast cancer, an estrogen-anchored cyclodextrin
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